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Article Publish Status: FREE
Abstract Title:

Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway.

Abstract Source:

Sci Rep. 2015 ;5:13668. Epub 2015 Sep 2. PMID: 26329643

Abstract Author(s):

Shulan Su, Jinao Duan, Ting Chen, Xiaochen Huang, Erxin Shang, Li Yu, Kaifeng Wei, Yue Zhu, Jianming Guo, Sheng Guo, Pei Liu, Dawei Qian, Yuping Tang

Article Affiliation:

Shulan Su

Abstract:

Frankincense and myrrh are highly effective in treatment of inflammatary diseases, but lacking of the therapy mechanisms. We undertook this stuty to evaluate the effects on Adjuvant-induced Arthritis (AIA) rats and to explore the underlying mechanisms by analyzing the metabolic profiling and signaling pathway evaluated by expression of inflammatory cytokines, c-jun and c-fos and corresponding phosphorylation levels. The results stated the elevated expression levels of TNFα, PGE2, IL-2, NO, and MDA in serum and swelling paw of AIA rats were significantly decreased after treatment, which exerted more remarkable inhibitive effects of combined therapy. The metbolic profiling of plasma and urine were clearly improved and twenty-one potential biomarkers were identified.Moreover, the inhibited effects of five bioactive components on cytokine transcription in PHA stimulated-PBMC showed the MAPK pathway might account for this phenomenon with considerable reduction in phosphorylated forms of all the three MAPK (ERK1/2, p38 and JNK) and down regulation of c-jun and c-fos.

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Sayer Ji
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