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Abstract Title:

[Therapeutic use and profile of toxicity of the FOLFOX4 regimen].

Abstract Source:

Farm Hosp. 2009 Mar-Apr;33(2):89-95. PMID: 19480796

Abstract Author(s):

B Fernández-Lobato, M S Díaz-Carrasco, A Pareja, M Marín, N Vila, A de la Rubia

Article Affiliation:

Servicio de Farmacia, Hospital Universitario Virgen de la Arrixaca, Murcia, España.

Abstract:

INTRODUCTION: Since the publication of the MOSAIC test results in 2004, the FOLFOX4 regimen has been established as an adjuvant treatment which is recommended in stage III colorectal cancer. The aim of this study is to assess the use of this regimen in our field and to describe its toxicity. METHODS: Descriptive study of treatments with FOLFOX4 prescribed between April 2005 and March 2007. The data was obtained from the Farhos Oncología programme and clinical records. The following data was collected: age, gender, diagnosis, stage of the illness (TNM classification) and adverse reactions, expressing severity according to Common Toxicity Criteria 2.0. RESULTS: The FOLFOX4 regimen was prescribed for 39 patients (24 men and 15 women) with an average age of 59. The diagnoses were: 28 colon cancer (4 stage II, 17 stage III, and 7 stage IV), 10 rectal cancer (1 stage II, 4 stage III, and 5 stage IV) and 1 stage IV gastric cancer. The most frequent adverse reactions were peripheral neuropathy (82 %), neutropenia (56.4 %) and diarrhoea (53.9 %.) When the study was completed, 9 patients continued active treatment with the regimen (average 6.8 cycles.) Of the 30 remaining patients only 16 people completed the 12 planned cycles. 14 patients stopped their treatment (an average of 8.1 cycles) due to toxicity in 10 cases, clinical progression in 3 cases and one patient died. Of the total 368 cycles administered, 68 suffered administration delays and 22 had the dosage reduced. CONCLUSION: The use of the FOLFOX4 regimen has been adjusted to uses with some solid scientific evidence, but its toxicity has limited its use and hasmade administering the planned dosage levels difficult.

Study Type : Human Study
Additional Links
Problem Substances : FOLFOX : CK(10) : AC(1)

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Sayer Ji
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