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Abstract Title:

Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors ofα-amylase activity.

Abstract Source:

Bioorg Med Chem Lett. 2013 May 15 ;23(10):3007-12. Epub 2013 Mar 16. PMID: 23583514

Abstract Author(s):

Christophe Hano, Sullivan Renouard, Roland Molinié, Cyrielle Corbin, Esmatullah Barakzoy, Joël Doussot, Frédéric Lamblin, Eric Lainé

Article Affiliation:

Laboratoire de Biologie des Ligneux et des Grandes Cultures UPRES EA 1207, Equipe Lignanes des Linacées, Antenne Scientifique Universitaire de Chartres, 21 rue de Loigny la Bataille, F28000 Chartres, France. christophe.hano@univ-orleans.fr

Abstract:

Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreaticα-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM.

Study Type : Review

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Sayer Ji
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