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Article Publish Status: FREE
Abstract Title:

Anthelmintic activity of silver-extract nanoparticles synthesized from the combination of silver nanoparticles and M. charantia fruit extract.

Abstract Source:

BMC Complement Altern Med. 2016 ;16:242. Epub 2016 Jul 26. PMID: 27457362

Abstract Author(s):

Md Mamun Or Rashid, Jannatul Ferdous, Sujan Banik, Md Rabiul Islam, A H M Mazbah Uddin, Fataha Nur Robel

Article Affiliation:

Md Mamun Or Rashid

Abstract:

BACKGROUND: Present study has been conducted to know the anthelmintic activity of polyaniline coated silver nanoparticles (AgNPs) synthesized from Momordica charantia fruit extract.

METHODS: By reduction of AgNO3 in presence of NaBH4, silver nanoparticles were prepared. After mixing silver nanoparticles and extracts, coating was given on nanoparticles using polyaniline. Prepared nanoparticles were characterized by Visual, UV, FTIR spectroscopy, SEM techniques, and TEM analysis.

RESULTS: The FTIR results implied that AgNPs were successfully synthesized and capped with bio-compounds present in the extract. The result showed that death times of worm were 35.12 ± 0.5 and 59.3 ± 0.3 minutes for M. charantia extract and Ag-nanoparticles individually. But when these two combined together, paralysis and death time fall drastically which were only 6.16 ± 0.6 and 9.1 ± 0.4 minutes respectively. Albendazole tablet was used as standard, whichmade worms death in 3.66 ± 0.1 minutes.

CONCLUSION: Ag-Extract NPs showed strong anthelmintic activity against worm. This study has paved the way for further research to design new anthelmintic drug from the combination of M. charantia and AgNPs.

Study Type : Animal Study

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