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Article Publish Status: FREE
Abstract Title:

Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.

Abstract Source:

Stem Cell Reports. 2018 Oct 9 ;11(4):944-958. Epub 2018 Sep 20. PMID: 30245210

Abstract Author(s):

Lauriane Sèdes, Christèle Desdoits-Lethimonier, Betty Rouaisnel, Hélène Holota, Laura Thirouard, Laurianne Lesne, Christelle Damon-Soubeyrand, Emmanuelle Martinot, Jean-Paul Saru, Séverine Mazaud-Guittot, Françoise Caira, Claude Beaudoin, Bernard Jégou, David H Volle

Article Affiliation:

Lauriane Sèdes

Abstract:

Several studies have reported an association between the farnesoid X receptor alpha (FXRα) and estrogenic signaling pathways. Fxrα could thus be involved in the reprotoxic effects of endocrine disruptors such as bisphenol-A (BPA). To test this hypothesis, mice were exposed to BPA and/or stigmasterol (S), an FXRα antagonist. Following the exposure to both molecules, wild-type animals showed impaired fertility and lower sperm cell production associated with the alteration of the establishment and maintenance of the undifferentiated germ cell pool. The crosstalk between BPA and FXRα is further supported by the lower impact of BPA in mice genetically ablated for Fxrα and thefact that BPA counteracted the effects of FXRα agonists. These effects might result from the downregulation of Fxrα expression following BPA exposure. BPA and S act additively in human testis. Our data demonstrate that FXRα activity modulates the impact of BPA on male gonads and on undifferentiated germ cell population.

Study Type : In Vitro Study

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Sayer Ji
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