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Abstract Title:

Depleted uranium induces sex- and tissue-specific methylation patterns in adult zebrafish.

Abstract Source:

J Environ Radioact. 2016 Apr ;154:25-33. Epub 2016 Jan 29. PMID: 26829549

Abstract Author(s):

Kewin Gombeau, Sandrine Pereira, Jean-Luc Ravanat, Virginie Camilleri, Isabelle Cavalie, Jean-Paul Bourdineaud, Christelle Adam-Guillermin

Article Affiliation:

Kewin Gombeau

Abstract:

We examined the effects of chronic exposure to different concentrations (2 and 20μg L(-)(1)) of environmentally relevant waterborne depleted uranium (DU) on the DNA methylation patterns both at HpaII restriction sites (5'-CCGG-3') and across the whole genome in the zebrafish brain, gonads, and eyes. We first identified sex-dependent differences in the methylation level of HpaIIsites after exposure. In males, these effects were present as early as 7 days after exposure to 20 μg L(-)(1) DU, and were even more pronounced in the brain, gonads, and eyes after 24 days. However, in females, hypomethylation was only observed in the gonads after exposure to 20 μg L(-)(1) DU for24 days. Sex-specific effects of DU were also apparent at the whole-genome level, because in males, exposure to 20 μg L(-)(1) DU for 24 days resulted in cytosine hypermethylation in the brain and eyes and hypomethylation in the gonads. In contrast, in females, hypermethylation was observed in thebrain after exposure to both concentrations of DU for 7 days. Based on our current knowledge of uranium toxicity, several hypotheses are proposed to explain these findings, including the involvement of oxidative stress, alteration of demethylation enzymes and the calcium signaling pathway. This study reports, for the first time, the sex- and tissue-specific epigenetic changes that occur in a nonhuman organism after exposure to environmentally relevant concentrations of uranium, which could induce transgenerational epigenetic effects.

Study Type : Animal Study

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