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Abstract Title:

Enhanced cytotoxic and apoptotic potential in hepatic carcinoma cells of chitosan nanoparticles loaded with ginsenoside compound K.

Abstract Source:

Carbohydr Polym. 2018 Oct 15 ;198:537-545. Epub 2018 Jun 30. PMID: 30093032

Abstract Author(s):

Jianmei Zhang, Yijun Wang, Yunyao Jiang, Tingwu Liu, Yanyan Luo, Enjie Diao, Yufeng Cao, Liang Chen, Liang Zhang, Qian Gu, Jinyi Zhou, Fengting Sun, Wancai Zheng, Jianxun Liu, Xueqin Li, Weicheng Hu

Article Affiliation:

Jianmei Zhang

Abstract:

Ginsenoside compound K (CK) has been shown to exhibit anticancer properties. In this study, chitosan nanoparticles loaded with ginsenoside compound K (CK-NPs) were prepared as a delivery system using a self-assembly technique with amphipathic deoxycholic acid-O carboxymethyl chitosan as the carrier, which improved the water solubility of CK. By evaluating drug loading, entrapment efficiency, and in vitro release behavior, the feasibility of CK-NPs as a drug carrier nanoparticle for the treatment of human hepatic carcinoma cells (HepG2) was investigated. Result revealed that CK and CK-NPs showed a dose-dependent inhibitory effect on HepG2 cells with ICvalues of 23.33 and 16.58 μg/mL, respectively. Furthermore, fluorescence imaging demonstrated that CK-NPs promoted cellular uptake in vitro. Therefore, all results indicated that CK-NPs might be a novel drug delivery system to improve the solubility and enhance the cytotoxic and apoptotic potentials of CK for effective liver cancer chemotherapy.

Study Type : In Vitro Study

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