Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy. - GreenMedInfo Summary
Antitumor activity of the tea polyphenol epigallocatechin-3-gallate encapsulated in targeted vesicles after intravenous administration.
Nanomedicine (Lond). 2013 Feb ;8(2):181-92. Epub 2012 Aug 14. PMID: 22891867
AIM: The therapeutic potential of epigallocatechin-3-gallate (EGCG), a green tea polyphenol with anticancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study was to determine whether a tumor-targeted vesicular formulation of EGCG would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo.
MATERIALS & METHODS: Transferrin-bearing vesicles encapsulating EGCG were administered intravenously to mice bearing subcutaneous A431 and B16-F10 tumors.
RESULTS: The intravenous administration of EGCG encapsulated in transferrin-bearing vesicles resulted in tumor suppression in 40% of A431 and B16-F10 tumors. Animal survival was improved by more than 20 days compared with controls.
CONCLUSION: Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.