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Abstract Title:

Inhibition of gastric H+, K(+)-ATPase and acid secretion by ellagic acid.

Abstract Source:

Mol Nutr Food Res. 2008 Jun;52(6):692-700. PMID: 1663631

Abstract Author(s):

S Murakami, Y Isobe, H Kijima, H Nagai, M Muramatu, S Otomo

Article Affiliation:

Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.

Abstract:

The effects of ellagic acid on gastric H+, K(+)-ATPase, acid secretion, and the occurrence of gastric ulcers were studied. Ellagic acid inhibited hog gastric H+, K(+)-ATPase activity with a 50% inhibition at 2.1 x 10(-6)M; kinetic studies showed that the inhibition of H+, K(+)-ATPase by ellagic acid is competitive with respect to ATP and is noncompetitive with respect to K+. The effect on gastric ulcers was investigated by using a stress ulcer model. Intraperitoneal administration of ellagic acid at above 5 mg/kg markedly reduced the occurrence of gastric lesion. Ellagic acid significantly reduced acid secretion at the same doses. These results suggest that ellagic acid has a marked inhibitory effect on acid secretion and the occurrence of stress-induced gastric lesions, and these effects may be attributed to the inhibition of H+, K(+)-ATPase activity.

Study Type : Animal Study

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Sayer Ji
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