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Abstract Title:

β-elemene inhibits tumor-promoting effect of M2 macrophages in lung cancer.

Abstract Source:

Biochem Biophys Res Commun. 2017 08 19 ;490(2):514-520. Epub 2017 Jun 15. PMID: 28624450

Abstract Author(s):

Xiaomu Yu, Maoyi Xu, Na Li, Zongjuan Li, Hongye Li, Shujuan Shao, Kun Zou, Lijuan Zou

Article Affiliation:

Xiaomu Yu

Abstract:

Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs).β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examined the effect of β-elemene on macrophages to elucidate a novel mechanism of β-elemene in tumor therapy. We showed that the conditionedmedium of M2 macrophages promoted lung cancer cells to migration, invasion and epithelial mesenchymal transition, which could be inhibited by β-elemene. Moreover, β-elemene regulated the polarization of macrophages from M2 to M1. β-elemene also inhibited the proliferation, migration, invasion oflung cancer cells and enhanced its radiosensitivity. These results indicate β-elemene suppresses lung cancer by regulating both macrophages and lung cancer cells, it is a promising drug for combination with chemotherapy or radiotherapy.

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Sayer Ji
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