Efficacy of grape seed extract gel in the treatment of chronic periodontitis - GreenMedInfo Summary
Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study.
J Investig Clin Dent. 2018 May ;9(2):e12318. Epub 2018 Jan 18. PMID: 29349878
AIM: The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis.
METHODS: Eighty-six sites with pocket depth (PD)>4 mm were selected from five systemically-healthy patients in whom scaling, and root planing were performed, and oral instructions were given, a week earlier. PD, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were measured, and sites were then divided into the control group (N = 38) and GSE group (N = 48). Four doses of formulated 2% mucoadhesive GSE gel were applied to GSE group sites at baseline visit (T0), and 3, 6, and 9 days after T0. Similarly, a control gel was applied to the control sites. PD, PI, GI and BOP were re-evaluated after 4 weeks and 6 months offirst gel application.
RESULTS: Paired t test for both the control and GSE groups showed a significant reduction for all variables after 6 months of gel application (P < .05). The independent t test showed a significant difference (P < .05) only in the reduction of gingival index (mean: 0.85 ± 0.77 for control and 1.3 ± 0.8 for GSE) and plaque index (mean: 0.75 ± 0.71 for control and 1.12 ± 0.7 for GSE).
CONCLUSION: The subgingival application of the formulated 2% mucoadhesive GSE gel showed significant improvement in the PI and GI only.