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Abstract Title:

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells.

Abstract Source:

J Agric Food Chem. 2019 Jan 29. Epub 2019 Jan 29. PMID: 30694659

Abstract Author(s):

Long Ma, Xiuqi Cao, Haiyue Wang, Kui Lu, Ying Wang, Chunhao Tu, Yujie Dai, Yuanyuan Meng, Yuyin Li, Peng Yu, Shuli Man, Aipo Diao

Article Affiliation:

Long Ma

Abstract:

Human flap endonuclease 1 (hFEN1) is instrumental in DNA replication and repair. It is able to cleave the 5' single-stranded protrusion (also known as 5' flap) resulting from strand displacement reactions. In light of its crucial functions, hFEN1 is now deemed as a nontrivial target in the DNA damage response system for anticancer drug development. Herein, we report that myricetin and some natural flavonoids are able to inhibit hFEN1. Structure-activity relationship, inhibitory mechanisms, molecular docking, and cancer cell-based assays have been performed. Our original findings expand the activity of flavonoids and may pave the way for flavonoid-assisted targeted cancer therapy.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Chemosensitizer : CK(772) : AC(577)

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Sayer Ji
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