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Article Publish Status: FREE
Abstract Title:

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4 Induced Liver Toxicity in Rat.

Abstract Source:

J Pharm (Cairo). 2017 ;2017:6081374. Epub 2017 Jan 15. PMID: 28182107

Abstract Author(s):

Ebrahim Abbasi Oshaghi, Iraj Khodadadi, Fatemeh Mirzaei, Mozafar Khazaei, Heidar Tavilani, Mohammad Taghi Goodarzi

Article Affiliation:

Ebrahim Abbasi Oshaghi

Abstract:

The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats' liver. Thiol groups' oxidation, amyloid cross-β, and protein fragmentation (P<0.001) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (P<0.05). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.

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Sayer Ji
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