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Abstract Title:

Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice.

Abstract Source:

BMC Pharmacol. 2002 Dec 19;2:21. Epub 2002 Dec 19. PMID: 12493079

Abstract Author(s):

Hossein Hosseinzadeh, Gholam Reza Karimi, Maryam Ameri

Article Affiliation:

Pharmaceutical Research Center and Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. hosseinzadehh@yahoo.com

Abstract:

BACKGROUND: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice. RESULTS: Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. CONCLUSIONS: The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Ulcer Agents : CK(390) : AC(140)

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