Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Purified rutin and rutin-rich asparagus attenuate colitis severity and tissue damage following dextran sodium sulphate-induced colitis.

Abstract Source:

Mol Nutr Food Res. 2016 Jun 28. Epub 2016 Jun 28. PMID: 27349947

Abstract Author(s):

Krista A Power, Jenifer T Lu, Jennifer M Monk, Dion Lepp, Wenqing Wu, Claire Zhang, Ronghua Liu, Rong Tsao, Lindsay E Robinson, Geoffrey A Wood, David J Wolyn

Article Affiliation:

Krista A Power

Abstract:

SCOPE: This study investigated the effects of cooked whole asparagus versus its equivalent level of purified flavonoid glycoside, rutin, on dextran sodium sulphate (DSS)-induced colitis and subsequent colitis recovery in mice.

METHODS AND RESULTS: C57BL/6 male mice were fed an AIN-93G basal diet (BD), or BD supplemented with 2% cooked asparagus (ASP) or 0.025% rutin (RUT) for 2 weeks prior to and during colitis induction with 2% DSS in water for 7 days, followed by 5 days colitis recovery. In colitic mice, both ASP and RUT upregulated mediators of improved barrier integrity and enhanced mucosal injury repair (e.g. Muc1, IL-22, Rho-A, Rac1, and Reg3γ), increased the proportion of mouse survival, and improved disease activity index. RUT had the greatest effect in attenuating DSS-induced colonic damage indicated by increased crypt and goblet cell restitution, reduced colonic myeloperoxidase, as well as attenuated DSS-induced microbial dysbiosis(reduced Enterobacteriaceae and Bacteroides, and increased unassigned Clostridales, Oscillospira, Lactobacillus, and Bifidobacterium).

CONCLUSION: These findings demonstrate that dietary cooked asparagus and its flavonoid glycoside, rutin, may be useful in attenuating colitis severity by modulating the colonic microenvironment resulting in reduced colonic inflammation, promotion of colonic mucosal injury repair, and attenuation of colitis-associated microbial dysbiosis. This article is protected by copyright. All rights reserved.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.