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Abstract Title:

Curcumol induces apoptosis in SPC-A-1 human lung adenocarcinoma cells and displays anti-neoplastic effects in tumor bearing mice.

Abstract Source:

Asian Pac J Cancer Prev. 2015 ;16(6):2307-12. PMID: 25824755

Abstract Author(s):

Qi-Ling Tang, Ji-Quan Guo, Qi-You Wang, Hai-Shu Lin, Zhou-Ping Yang, Tong Peng, Xue-Diao Pan, Bing Liu, Su-Jun Wang, Lin-Quan Zang

Article Affiliation:

Qi-Ling Tang

Abstract:

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.

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Sayer Ji
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