Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus. - GreenMedInfo Summary
Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.
Curr Clin Pharmacol. 2018 Jan 3. Epub 2018 Jan 3. PMID: 29299989
OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin.
METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period. 118 patients with type 2 diabetes were recruited of whom 50 control and 50 active subjects completed the trial. Adiponectin, leptin, ghrelin and tumor necrosis factor-α (TNF-α) were measured at baseline and 12 weeks.
RESULTS: Between group comparison of the magnitude of changes showed serum levels of leptin (p<0.001), TNF-α (p<0.001) and leptin:adiponectin ratio (p<0.001) to be significantly reduced while serum adiponectin levels were elevated in the curcuminoids versus placebo group (p=0.032). Changes in serum ghrelin levels did not differ between the study groups (p=0.135). These effects remained statistically unaltered after adjustment for baseline values or changes in BMI. However, serum ghrelin levels were found to be significantly elevated following curcuminoid supplementation after adjustment for baseline ghrelin concentrations (p=0.017) or changes in BMI (p=0.025).
CONCLUSION: Curcumin supplementation increased adiponectin, whilst the the leptin:adiponectin ratio (a measure of atherosclerosis) and leptin levels were decreased independent of weight change and reflected a decrease in the inflammatory TNF-α levels.