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Abstract Title:

Protective effect of curcumin in rat liver injury induced by carbon tetrachloride.

Abstract Source:

Int J Cancer. 2005 Mar 20;114(2):190-4. PMID: 10813555

Abstract Author(s):

E J Park, C H Jeon, G Ko, J Kim, D H Sohn

Article Affiliation:

College of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Cheonbuk, South Korea.

Abstract:

This study was carried out to investigate the protective effects of curcumin on acute or subacute carbon tetrachloride-induced liver damage in rats. Acute hepatotoxicity was induced by intraperitoneal injection of carbon tetrachloride after 4 consecutive days of curcumin treatment. Subacute hepatotoxicity was induced by oral administration of carbon tetrachloride twice a week during 4 weeks of curcumin treatment. In rats with acute liver injury, curcumin (100 and 200 mg kg(-1)) lowered the activity of serum alanine aminotransferase to 52-53% (P<0.05) and aspartate aminotransferase to about 62% (P<0.05) those of control rats. In rats with subacute liver injury, curcumin (100 mg kg(-1)) lowered the activity of serum alanine aminotransferase to 34% (P<0.01) and alkaline phosphatase to 53% (P<0.05) of control rats. The liver hydroxyproline content in the curcumin (100 mg kg(-1))-treated group was reduced to 48% of the carbon tetrachloride control group (P<0.01). Malondialdehyde levels in curcumin (100 mg kg(-1)) treated rat liver was decreased to 67% of the control rat liver (P<0.01) in subacute injury. It was concluded that curcumin improved both acute and subacute liver injury induced by carbon tetrachloride in rats.

Study Type : Animal Study

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Sayer Ji
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