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Abstract Title:

Curcumin prevents paracetamol-induced liver mitochondrial alterations.

Abstract Source:

J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315

Abstract Author(s):

Luis Fernando Granados-Castro, Daniela Sarai Rodríguez-Rangel, Berenice Fernández-Rojas, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Omar Noel Medina-Campos, Dianelena Eugenio-Pérez, Enrique Pinzón, José Pedraza-Chaverri

Article Affiliation:

Luis Fernando Granados-Castro

Abstract:

OBJECTIVE: In the present study was evaluated if curcumin is able to attenuate paracetamol (PCM)-induced mitochondrial alterations in liver of mice.

METHODS: Mice (n = 5-6/group) received curcumin (35, 50 or 100 mg/kg bw) 90 min before PCM injection (350 mg/kg bw). Plasma activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was measured; histological analyses were done; and measurement of mitochondrial oxygen consumption, mitochondrial membrane potential, ATP synthesis, aconitase activity and activity of respiratory complexes was carried out.

KEY FINDINGS: Curcumin prevented in a dose-dependent manner PCM-induced liver damage. Curcumin (100 mg/kg) attenuated PCM-induced liver histological damage (damaged hepatocytes from 28.3± 7.7 to 8.3 ± 0.7%) and increment in plasma ALT (from 2300 ± 150 to 690 ± 28 U/l) and AST (from 1603 ± 43 to 379 ± 22 U/l) activity. Moreover, curcumin attenuated the decrease in oxygen consumption using either succinate or malate/glutamate as substrates (evaluated by state 3, respiratory control ratio, uncoupled respiration and adenosine diphosphate/oxygen ratio), in membrane potential, in ATP synthesis, in aconitase activity and in the activity of respiratory complexes I, III and IV.

CONCLUSIONS: These results indicate that the protective effect of curcumin in PCM-induced hepatotoxicity is associated with attenuation of mitochondrial dysfunction.

Study Type : Animal Study

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