Curcumin prevents the migration of nasopharyngeal cancer cells. - GreenMedInfo Summary
Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin.
Anticancer Res. 2010 Jul;30(7):2851-6. PMID: 20683022
Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, China. email@example.com
BACKGROUND: Curcumin is a natural polyphenol. It is a potent suppressor of nuclear factor kappa B (NF-kappaB). High NF-kappaB levels have suppressive effect on E-cadherin (molecule related to cell-cell adhesion) in nasopharyngeal carcinoma (NPC) cells. We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells.
MATERIALS AND METHODS: NPC cell lines HK1 and HONE1 were used. Real-time quantitative PCR and Western blotting were used to examine the expression changes of NF-kappaB and E-cadherin. A mouse xenograft model was used to validate the results.
RESULTS: With curcumin treatment, NF-kappaB was down-regulated and E-cadherin was up-regulated in NPC cells. The negative correlation of NF-kappaB and E-cadherin was confirmed in the mouse xenograft model.
CONCLUSION: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-kappaB and activating E-cadherin expression.