Tetrahydrocurcumin confers protection against amyloidβ-induced toxicity.
Neuroreport. 2010 Nov 24. Epub 2010 Nov 24. PMID: 21116204
National Brain Research Centre, Manesar, Haryana, India.
Amyloid plaques and neurofibrillary tangles are the hallmarks of Alzheimer's disease. Amyloidβ, a primary component of the amyloid plaques, is neurotoxic. Considerable attention has been directed toward identifying compounds with neuroprotective properties. Using rat primary hippocampal cultures, we show that tetrahydrocurcumin (THC), a metabolite of curcumin, shows a protective effect against oligomeric amyloid-β-induced toxicity. We further show that THC reduces amyloid-β-induced (i) increase in the level of reactive oxygen species, (ii) decrease in mitochondrial membrane potential, and (iii) caspase activation. In addition, we show that THC protects human neurons from oligomericamyloid-β-induced toxicity as well. Thus, THC confers protection against amyloid-β-induced toxicity, and the antioxidant activity may contribute to its protective effect.