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Abstract Title:

Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats.

Abstract Source:

Evid Based Complement Alternat Med. 2008 Sep;5(3):281-7. PMID: 20172017

Abstract Author(s):

Tse-Chou Cheng, Chih-Cheng Lu, Hsien-Hui Chung, Chih-Chieh Hsu, Nozomi Kakizawa, Shizuo Yamada, Juei-Tang Cheng

Article Affiliation:

Department of Urology and Department of Medical Research, Chi-Mei Medical Center, Yong Kang City, Taiwan, ROC.

Abstract:

Curcumin is an active principle contained in rhizome of Curcuma longa, and it has been recently mentioned to show affinity to muscarinic M-1 cholinoceptors (M(1)-mAChR). In the present study, we found that curcumin caused a concentration-dependent increase of muscle tone in urinary bladder isolated from Wistar rats. This action was inhibited by pirenzepine at concentration enough to block M(1)-mAChR. In radioligand-binding assay, specific binding of [(3)H]-oxotremorine (OXO-M) in the rat bladder homogenates was also displaced by curcumin in a concentration-dependent manner. In the presence of inhibitors for PLC-PKC pathway, either U73122 (phospholipase C inhibitor) or chelerythrine (protein kinase C inhibitor), curcumin-stimulated contraction in urinary bladder was markedly reduced. In conclusion, the obtained results suggest that curcumin can activate M(1)-mAChR at concentrations lower than to scavenge free radicals to increase of muscle tone in urinary bladder through PLC-PKC pathway.

Study Type : Animal Study

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