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Abstract Title:

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer.

Abstract Source:

Ecancermedicalscience. 2015 ;9:525. Epub 2015 Apr 23. PMID: 25932049

Abstract Author(s):

Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

Article Affiliation:

Alok Mishra

Abstract:

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Study Type : In Vitro Study

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Sayer Ji
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