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Abstract Title:

Metabolic intervention of aflatoxin B1 toxicity by curcumin.

Abstract Source:

J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472

Abstract Author(s):

Sujatha Nayak, R B Sashidhar

Article Affiliation:

Department of Biochemistry, University College of Science, Osmania University, Hyderabad, AP, India.

Abstract:

UNLABELLED: ETHNO PHARMACOLOGICAL RELEVANCE: Curcumin, bioactive principle of turmeric (Curcuma longa Linn) is an important constituent of Indian traditional medicine. Turmeric has been known to possess several therapeutic properties.

AIM OF THE STUDY: The modulatory effect of dietary curcumin (0.05%, w/w) on drug metabolizing and general marker enzymes of liver and formation of AFB(1)-adducts (DNA and protein) due to dietary AFB(1) exposure for a period of 6 weeks in a rodent model, have been evaluated.

MATERIALS AND METHODS: Drug metabolizing enzymes CYP1A1, GSHT, UGT1A and general marker enzymes (LDH, ALT, AST, ALP and gamma-GT) of liver were estimated by standardized methods. Aflatoxin adducts (DNA and protein) were quantitated by indirect competitive ELISA.

RESULTS: Dietary curcumin enhanced GSHT (p<0.001) and UGT1A1 (p<0.05) activity and significantly reduced the activity of CYP1A1 (p<0.001), in rats exposed to aflatoxin B(1). Supplementation of curcumin in the diet normalized the altered activities of LDH and ALT. At molecular level, curcumin significantly reduced AFB(1)-N(7)-guanine adduct (p<0.001) excretion in the urine, DNA adduct (p<0.05) in the liver and albumin adduct (p<0.001) in the serum.

CONCLUSION: The experimental results substantiates that curcumin intervention ameliorates the AFB(1) induced toxicity.

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