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Curcumin inhibits liver fibrosis. - GreenMedInfo Summary

Abstract Title:

Curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro.

Abstract Source:

J Pharm Pharmacol. 2002 Jan;54(1):119-26. PMID: 11829122

Abstract Author(s):

Hee-Chul Kang, Ji-Xing Nan, Pil-Hoon Park, Ji-Young Kim, Sung Hee Lee, Sun Wook Woo, Yu-Zhe Zhao, Eun-Jeon Park, Dong Hwan Sohn

Article Affiliation:

Department of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk, South Korea.

Abstract:

We previously demonstrated that curcumin, a well-known antioxidant, inhibits collagen deposition in carbon tetrachloride-induced liver injury in rats. The major effector cells responsibleforcollagensynthesis in the liver are activated hepatic stellate cells. In this study,we investigated the inhibitory effects of curcumin on the collagen synthesis and activation of rat hepatic stellate cells in-vitro, and on hepatic stellate cell activation in-vivo. The effects of curcumin on the production of collagen and smooth muscle alpha-actin proteins and of alpha1(I) collagen mRNA were studied in-vivo and in-vitro. The effect of curcumin on DNA synthesis was also determined in-vitro. In-vivo, treatment with curcumin reduced collagen deposition and smooth muscle alpha-actin-positive areas and lowered mRNA levels of type I collagen in the liver. In-vitro, curcumin at a concentration of 5 microg mL(-1) reduced DNA synthesis, and downregulated smooth muscle alpha-actin and type I collagen expression, and alpha1(I) collagen mRNA expression. We concluded that curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro, and thus may prove a valuable anti-fibrogenic agent.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29)

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Sayer Ji
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