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Abstract Title:

[Curcumin inhibits hypoxia-induced proliferation of MRC-5 and collagen I synthesis].

Abstract Source:

Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;41(4):621-5. PMID: 20848782

Abstract Author(s):

Zheng-Ping He, Min Xie

Article Affiliation:

Department of Respiratory, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract:

OBJECTIVE: To investigate the effect of curcumin on MRC-5 in human embryo fibroblast (HEF) under hypoxia and possible underlying mechanism.

METHODS: The MRC-5 were cultured in vivo under 5 different conditions, including normal control, SB203580 (10 micromol/L), LY-294002 (10 micromol/L) and curcumin (5,10 and 20 micromol/L, respectively). The proliferation of MRC-5 was assessed by MTT assay and the expressions of pro-collal, p-p38 and p-AKT were detected by western blot.

RESULTS: Compared with the nomoxia control, hypoxia enhanced the proliferation of MRC-5 and the expressions of pro-collal, p-p38 and p-AKT (P<0.05). Curcumin inhibited the hypoxia-induced proliferation of MRC and the expression of pro-collal and p-p38 (P<0.05), but not the expression of p-AKT (P>0.05).

CONCLUSION: Hypoxia might enhance the proliferation of MRC-5 cells and the expression of collagen I through PI3K/AKT and p38MAPK. Curcumin blocks the hypoxia influence through is impact on p38MAPK.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-Proliferative : CK(59) : AC(52)

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