Curcumin inhibits hepatitis B virus. - GreenMedInfo Summary
Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha.
FEBS Lett. 2010 Jun 3;584(11):2485-90. Epub 2010 Apr 29. PMID: 20434445
The Institute of Gastroenterology and Liver Disease, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1alpha, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.