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Abstract Title:

[Curcumin inhibits growth, induces G1 arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2/Bax].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):2022-5. PMID: 19086645

Abstract Author(s):

Zhi-qiang Chen, Xiao Jie, Zeng-nan Mo

Article Affiliation:

Institute of Urology&Nephrology, First Affiliated Hospital, Guangxi Medical Universuity, Nanning 530021, China.

Abstract:

OBJECTIVE: To investigate the effect of curcumin on apoptosis of human prostatic stromal cells.

METHOD: Different concentrations of curcumin were added into culture media system to induce apoptosis of human prostatic stromal cells. The apoptosis was detected by MTT assay, flow cytometry, RT-PCR and TUNEL method.

RESULT: Curcumin at concentrations of 10-40 micromol x L(-1) could inhibit the proliferation of human prostatic stromal cells in a doseand time-dependent manner (P<0.05). Characteristic apoptosis were confirmed by TUNEL RT-PCR manifest downregulation of Bcl-2/Bax (P<0.05). Cell cycle was arrested into G1 phase by curcumin.

CONCLUSION: Curcumin can induce apoptosis in human prostatic stromal cells by down-regulation of Bcl-2/Bax.

Study Type : In Vitro Study

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Sayer Ji
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