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Abstract Title:

The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.

Abstract Source:

J Bras Pneumol. 2006 Jan-Feb;32(1):66-74. PMID: 10102956

Abstract Author(s):

A Rasyid, A Lelo

Article Affiliation:

Department of Radiology, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Abstract:

BACKGROUND: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder.

AIMS: To compare the effect of 20 mg curcumin or placebo on the gall-bladder volume of healthy volunteers.

METHODS: A randomized, double blind and crossover design study was carried out in 12 healthy volunteers (seven males and five females). Ultrasonography examination was carried out serially to measure the gall-bladder volume. The data obtained was analysed by paired Student's t-test.

RESULTS: The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P>0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo.

CONCLUSION: On the basis of the present findings, it appears that curcumin induces contraction of the human gall-bladder.

Study Type : Human Study

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