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Abstract Title:

[Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro].

Abstract Source:

Zhong Yao Cai. 2001 Sep;24(9):655-7. PMID: 11799777

Abstract Author(s):

H Zhang, L Yang, S Liu, L Ren

Article Affiliation:

North China Coal Medical College, Tangshan 063000.

Abstract:

OBJECTIVE: To screen drugs reversing multidrug resistance of tumor cells from active constituents of traditional Chinese medicine and to study the reversal action.

METHODS: The kill effects of the drugs on tumor cell lines in vitro were determined with MTT method. The Jin's formula was used to analyse the effect of drug combination.

RESULTS: 5 micrograms/ml rhynchophylline, 2 micrograms/ml jatrorrhizine and 1.25 micrograms/ml indirulin could reverse multidrug resistance for vincristine on KBv200 cell line by 16.8, 5.1 and 4 fold respectively. 1.56-12.5 micrograms/ml curcumine combining with vincristine could sensitize antitumor effect both on KB and KBv200 cell lines.

CONCLUSION: All rhynchophylline, jatrorrhizine and indirulin could reverse multidrug resistance for vincristine on KBv200 cell line. Curcumine combinating vincristine could sensitize antitumor effect both on kB and kBv200 cell lines.

Study Type : In Vitro Study

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Sayer Ji
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