Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Inhibitory effects of curcumin-free aqueous turmeric extract on benzo[a]pyrene-induced forestomach papillomas in mice.

Abstract Source:

Cancer Lett. 1997 Sep 16;118(1):79-85. PMID: 9310263

Abstract Author(s):

S S Deshpande, A D Ingle, G B Maru

Article Affiliation:

Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, India.

Abstract:

The modulating effects of curcumin-free aqueous turmeric extract (CFATE), ethanolic turmeric extract (ETE) and turmeric (T) powder on the benzo(a)pyrene (B(a)P)-induced forestomach tumors were investigated in Swiss female albino mice receiving oral administration of B(a)P at a dose of 1 mg twice weekly for 4 weeks. Administration of 0.2%/1.0%/5.0% turmeric-derived CFATE as sole source of drinking water or 0.01%/0.05%/0.25% ETE in diet or 0.2%/1.0%/5.0% T in diet, 2 weeks before, during and 2 weeks after the last dose of B(a)P (during initiation period) resulted in significant suppression of B(a)P-induced tumorigenesis when compared with the group receiving B(a)P and control diet/drinking water. Among different fractions tested, CFATE appears to be more powerful as not only did it reduce the tumor multiplicity to the lowest levels but it also significantly reduced the tumor incidence. Administration of 5.0% turmeric-derived CFATE as the sole source of drinking water or 0.25% ETE/5.0% T in diet starting from 48 h after the last dose of B(a)P (during the post-initiation period) until the termination of the experiment, also inhibited the formation of multiple gastric tumors by B(a)P, although the suppression of tumor multiplicity was appreciably more in the groups that received 5.0% turmeric-derived CFATE/0.25% ETE treatment during initiation with carcinogen, i.e. 2 weeks before, during and 2 weeks after the last dose of B(a)P. The present data clearly indicate the potential of turmeric-derived CFATE as a powerful chemopreventive fraction and also demonstrate the efficacy of lower, i.e. 1/25th and/or 1/5th of the reported, chemopreventive doses of T/ETE (essentially curcumins) in inhibiting B(a)P-induced forestomach tumors in mice.

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.