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Abstract Title:

[Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice].

Abstract Source:

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 May;25(5):399-401. PMID: 19426594

Abstract Author(s):

Zhen-you Jiang, Lin Zou, Shan-shan Shi, Yan-ru Lu, Jun Dong, Chun-hua Yang, Ye-cheng Lu, Guo-kui Dai

Article Affiliation:

Department of Microbiology and Immunology, Jinan University, Guangzhou, China. tjzhy@jnu.edu.cn

Abstract:

AIM: To study the effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice.

METHODS: 75 mice were divided into five groups. After treated with curcumin 6 and 9 mice of each group were sacrificed on day 14 and 42 respectively to take their blood and lung tissue. The level of TNF-alpha and TGF-beta1 was observed by ELISA.

RESULTS: The infection reaction of lung tissue and fibrosis in model group was obvious. Compared with sham operation group, TNF-alpha and TGF-beta1 in serum and lung tissue increased significantly(P<0.01), but decreased in different degrees after treated with curcumin(P<0.05).

CONCLUSION: Curcumin can decrease the level of TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice and have the anti-fibrosis role by deregulating cytokine level.

Study Type : Animal Study

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