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Abstract Title:

Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo.

Abstract Source:

Altern Ther Health Med. 2010 Mar-Apr;16(2):12-4. PMID: 20232614

Abstract Author(s):

Panayotis Pantazis, Aarthi Varman, Cindy Simpson-Durand, Jessica Thorpe, Satish Ramalingam, Dharmalingam Subramaniam, Courtney Houchen, Michael Ihnat, Shrikant Anant, Rama P Ramanujam

Article Affiliation:

Swaasth, Inc, Oklahoma City, Oklahoma, USA.

Abstract:

Trivalent arsenic [As(III)] is currently approved by the FDA for the treatment of chronic and acute leukemias. However, As(III) has also demonstrated damaging effects on human health, including development of cardiovascular disease, diabetes, and cancer. Further, As(III) is a potent angiogenic agent. In this context, curcumin, an active ingredient in the dietary agent turmeric, has demonstrated potent antiproliferative, antiinflammatory, and antiangiogenic properties. In this report, we have shown that both curcumin and turmeric inhibit expression of vascular endothelial growth factor in HCT-116 human colon cancer cells exposed to As(III). Further, in the chicken chorioallantoic membrane assay model, treatment with low As(III) concentrations results in extensive increase in blood vessel density, which, however, is reduced in the presence of curcumin or turmeric. Collectively, the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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