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Abstract Title:

[Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis].

Abstract Source:

Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):48-52. PMID: 15683997

Abstract Author(s):

Gang Xu, Wen Huang, Wei-min Zhang, Zhuo-sheng Lai, Mei-rong He, Ya-dong Wang, Ya-li Zhang

Article Affiliation:

Institute for Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xgvip@tom.com

Abstract:

OBJECTIVE: To examine the effect of combined use of curcumin and catechin on the number of aberrant crypt foci (ACF) and expression levels of cyclooxygenase-2 (COX-2) mRNA in rat colon carcinogenesis. Methods Dimethylhydrazine (DMH)-induced rats colon carcinogenesis model was used for evaluation of the synergistic inhibitory effect between curcumin and catechin in light of ACF formation and tumor incidence. COX-2 mRNA expression was also detected in rat colon carcinogenesis.

RESULTS: Curcumin, catechin and their co-treatment caused significant inhibition of DMH-induced ACF and colon carcinogenesis as compared with untreated DMH-induced rat models (P<0.01). Co-treatment with curcumin and catechins caused greater inhibition of DMH-induced ACF and colon carcinogenesis than the single use of curcumin or catechin (P<0.05). A synergistic inhibitory effect between curcumin and catechin on the expression of COX-2 mRNA was observed in the early stage of rat colon carcinogenesis but not in colon tumor tissues.

CONCLUSION: Curcumin and catechin have synergistic effect on ACF and COX-2 mRNA expression in rat colon carcinogenesis, suggesting their potential value in the prevention of human colon cancers.

Study Type : In Vitro Study

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