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Abstract Title:

Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation.

Abstract Source:

Biochem Biophys Res Commun. 2015 Apr 17 ;459(4):673-8. Epub 2015 Mar 10. PMID: 25767074

Abstract Author(s):

Zheng Jun Li, Jung-Min Shin, Dae-Kyoung Choi, Seul Ki Lim, Tae-Jin Yoon, Young Ho Lee, Kyung-Cheol Sohn, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee

Article Affiliation:

Zheng Jun Li

Abstract:

Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-κB and STAT3 signaling pathway in human keratinocytes. In addition, keratinocyte proliferation was markedly inhibited by cucurbitacin B. The potential beneficial effect of cucurbitacin B on psoriasis was further validated in imiquimod-induced psoriasiform dermatitis of experimental animal. Topicalapplication of cucurbitacin B resulted in significant reduction of epidermal hyperplasia and inflammatory cytokines production, and ameliorated the psoriatic symptom. Taken together, these results suggest that cucurbitacin B may be a potential candidate for the treatment of psoriasis.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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