Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: a randomized placebo-controlled trial.
Acta Odontol Scand. 2018 Jul ;76(5):331-337. Epub 2018 Mar 22. PMID: 29566582
OBJECTIVE: To examine a reducing effect of Lactobacillus paracasei SD1 on MS and caries in preschool children.
MATERIALS AND METHODS: A total of 124 children, aged 1.5-5 years old, participated and were randomly assigned to the probiotic or control group. The probiotic group received L. paracasei SD1-milk and the control group received standard-milk once daily for 3 months. MS/lactobacilli were enumerated and the caries score was examined. Association between probiotic consumption and bacterial level, or caries progression was assessed by a multivariate logistic regression. This study was registered at the Thai-Clinical-Trials-Registry (TCTR20140903001).
RESULTS: Probiotic was found to be a factor associated with the MS level. Children in the probiotic group had a significantly lower risk of an increase in the MS level than in the control group after receiving the probiotic milk at 3- and 4-months with p < .001 and p = .040, respectively. Probiotic significantly reduced the risk for caries compared to the control group (p = .016). There were no adverse effects or non-compliance reported in either group.
CONCLUSIONS: Consumption of milk powder containing L. paracasei SD1 resulted in a reduction of both salivary MS and delayed new caries development, and the strain is safe for use in young children. Results suggest that L. paracasei SD1 may be an alternative way for caries prevention in young children.