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Abstract Title:

Dietaryω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis.

Abstract Source:

JAMA Neurol. 2014 Jul 14. Epub 2014 Jul 14. PMID: 25023276

Abstract Author(s):

Kathryn C Fitzgerald, Eilis J O'Reilly, Guido J Falcone, Marjorie L McCullough, Yikyung Park, Laurence N Kolonel, Alberto Ascherio

Article Affiliation:

Kathryn C Fitzgerald

Abstract:

Importance: Amyotrophic lateral sclerosis (ALS) is a severe progressive disease that cannot be prevented or cured. Diet-derived long-chain polyunsaturated fatty acids (PUFAs) are incorporated in brain lipids and modulate oxidative and inflammatory processes and could thus affect ALS risk and progression.

Objective: To examine the association betweenω-6 and ω-3 PUFA consumption and ALS risk.

Design, Setting, and Participants: Longitudinal analyses based on 1 002 082 participants (479 114 women and 522 968 men) in 5 prospective cohorts: the National Institutes of Health-AARP Diet and Health Study, the Cancer Prevention Study II Nutrition Cohort, the Health Professionals Follow-up Study, the Multiethnic Cohort Study, and the Nurses' Health Study.Diet was assessed via food frequency questionnaire developed or modified for each cohort. Participants were categorized into cohort-specific quintiles of intake of energy-adjusted dietary variables.

Main Outcomes and Measures: Cohort-specific multivariable-adjusted risk ratios (RRs) of ALS incidence or death estimated by Cox proportional hazards regression and pooled using random-effects methods.

Results: A total of 995 ALS cases were documented during the follow-up. A greaterω-3 PUFA intake was associated with a reduced risk for ALS. The pooled, multivariable-adjusted RR for the highest to the lowest quintile was 0.66 (95% CI, 0.53-0.81; P < .001 for trend). Consumption of both α-linolenic acid (RR, 0.73; 95% CI, 0.59-0.89; P = .003 for trend) and marine ω-3 PUFAs (RR, 0.84; 95% CI, 0.65-1.08; P = .03 for trend) contributed to this inverse association. Intakes of ω-6 PUFA were not associated with ALS risk.

Conclusions and Relevance: Consumption of foods high inω-3 PUFAs may help prevent or delay the onset of ALS.

Study Type : Human Study

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