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Abstract Title:

Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis.

Abstract Source:

Biol Pharm Bull. 2008 Sep;31(9):1794-7. PMID: 18758079

Abstract Author(s):

Nao Otsuka, Mei-Hua Liu, Sumiko Shiota, Wakano Ogawa, Teruo Kuroda, Tsutomu Hatano, Tomofusa Tsuchiya

Article Affiliation:

Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, Japan.

Abstract:

We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-alpha-L-(2'',4''-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-alpha-L-(2''-Z-p-coumaroyl-4''-E-p-coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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