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Abstract Title:

[Active compounds from rhizomes of Musa basjoo].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(18):2424-7. PMID: 21141492

Abstract Author(s):

Qian Zhang, Wenyi Kang

Article Affiliation:

Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.

Abstract:

OBJECTIVE: To study the active compounds from the rhizomes of Musa basjoo.

METHOD: Antioxidant and alpha-glucosidase inhibitory activity of different extracts were tested. Using bioassay-guided fractionation, the chemical constituents in EtOAC extracts were isolated by column chromatography and identified by MS and NMR spectroscopy.

RESULT: Five compounds were isolated and identified as 2',3, 4'-trihydroxyflavone (1), 3,3'-bis-hydroxyanigorufone (2), irenolone (3), 4-dihydroxy-9-(4'-hydroxyphenyl)-phenalenone (4) and 3,4-dihydroxybenzaldehyde (5). Compound 1(IC50 8.61 mg x L(-1)), 3 (IC50 19.55 mg x L(-1)) and 5 (IC50 1.1 mg x L(-1)) had antioxidant activity. Compound 2 (IC50 24.15 mg x L(-1)) and 4(IC50 2.81 mg x L(-1)) had alpha-glucosidase inhibitory activity. Compound 5 showed MIC of 0.078, 0.313, 0.039 microg/disc against SA, MRSA and ESBLs, respectively.

CONCLUSION: Compound 1-5 were isolated from this plant for the first time. Compound 5 was isolated from the genus Musa for the first time. All compound except 5 were first reported about activity.

Study Type : In Vitro Study
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