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Article Publish Status: FREE
Abstract Title:

Compound K-induced apoptosis of human hepatocellular carcinoma MHCC97-H cells in vitro.

Abstract Source:

Oncol Rep. 2014 Jul ;32(1):325-31. Epub 2014 May 8. PMID: 24804620

Abstract Author(s):

Zhi-Zhong Zheng, Yan-Lin Ming, Liang-Hua Chen, Guo-Hua Zheng, Shao-Song Liu, Qing-Xi Chen

Article Affiliation:

Zhi-Zhong Zheng

Abstract:

An intestinal bacterial metabolite of ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (compound K), has been reported to induce apoptosis in a variety of cancer cells. However, the precise mechanisms induced by compound K in human hepatocellular carcinoma (HCC) cells remain unclear. In order to examine possible apoptotic mechanisms, we investigated the anticancer effect of compound K in MHCC97-H. MTT assay showed that compound K inhibited the proliferation of MHCC97-H cells with a relatively low toxicity in normal hepatoma cells. Cell cycle progression and cell staining showed an increase in apoptotic sub-G1 fraction. Treatment of MHCC97-H with compound K also induced a reduction in mitochondrial membrane potential (Δψm) and DNA damage. Further study showed that compound K upregulated Fas, FasL, Bax/Bcl-2 ratio and downregulated pro-caspase-9, pro-caspase-3 in a dose-dependent manner, and it also inhibited Akt phosphorylation.These results suggest that compound K significantly inhibits cell proliferation and induces apoptosis in MHCC97-H cells through Fas- and mitochondria-mediated caspase-dependent pathways in human HCC cells.

Study Type : In Vitro Study

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