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Abstract Title:

Cytotoxicity of purified cassava linamarin to a selected cancer cell lines.

Abstract Source:

Bioprocess Biosyst Eng. 2007 Jul;30(4):261-9. PMID: 17566787

Abstract Author(s):

Christopher Avwoghokoghene Idibie, Hajierah Davids, Sunny Esayegbemu Iyuke

Article Affiliation:

School of Chemical and Metallurgical Engineering, Faculty of Engineering, University of the Witwatersrand, Johannesburg, South Africa. krisid2007@yahoo.com

Abstract:

Cassava (Manihot esculenta Crantz) is a known source of linamarin, but difficulties associated with its isolation have prevented it from being exploited as a major source. A batch adsorption process using activated carbon proved successful in its isolation, with ultrafiltration playing a pivotal role in its purification. Thirty-two minutes of contact time was required for 60 g of extract, yielding 1.7 g of purified product. Picrate paper, infra-red and 'HNMR analysis confirmed the presence and structure of linamarin. Cytotoxic effects of linamarin on MCF-7, HT-29 and HL60 cells were determined using the MTT assay. Cytotoxic effects were significantly increased in the presence of linamarase (P-glucosidase), with a 10-fold decrease in the IC50 values obtained for HL-60 cells. This study thus describes a method for the isolation and purification of linamarin from cassava, as well as its cytotoxicity potential.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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