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Abstract Title:

Adverse Clinical Effects of Botulinum Toxin Intramuscular Injections for Spasticity.

Abstract Source:

Can J Neurol Sci. 2015 Nov 24:1-13. Epub 2015 Nov 24. PMID: 26597813

Abstract Author(s):

Chetan P Phadke, Chitra K Balasubramanian, Alanna Holz, Caitlin Davidson, Farooq Ismail, Chris Boulias

Article Affiliation:

Chetan P Phadke

Abstract:

OBJECTIVE: The adverse events (AEs) with botulinum toxin type-A (BoNTA), used for indications other than spasticity, are widely reported in the literature. However, the site, dose, and frequency of injections are different for spasticity when compared to the treatment for other conditions and hence the AEs may be different as well. The objective of this study was to summarize the AEs reported in Canada and systematically review the AEs with intramuscular botulinum toxin injections to treat focal spasticity.

METHODS: Data were gathered from Health Canada (2009-2013) and major electronic databases.

RESULTS: In a 4 year period, 285 AEs were reported. OnabotulinumtoxinA (n=272 events): 68% females, 53% serious, 18% hospitalization, and 8% fatalities. The type of AEs reported were - muscle weakness (19%), oropharyngeal (14%), respiratory (14%), eye related (8%), bowel/bladder related (8%), and infection (5%). IncobotulinumtoxinA (n=13): 38% females, 62% serious, and 54% hospitalization. The type of AEs reported were - muscle weakness (15%), oropharyngeal (15%), respiratory (38%), eye related (23%), bowel/bladder related (15%), and infection (15%). Commonly reported AEs in the literature were muscle weakness, pain, oropharyngeal, bowel/bladder, blood circulation, neurological, gait, and respiratory problems.

CONCLUSION: While BoNTA is useful in managing spasticity, future studies need to investigate the factors that can minimize AEs. A better understanding of the underlying mechanisms of the AEs can also improve guidelines for BoNTA administration and enhance outcomes.

Study Type : Human Study
Additional Links
Problem Substances : Botox : CK(20) : AC(1)

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Sayer Ji
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