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Article Publish Status: FREE
Abstract Title:

Inhibitory effect ofβ-elemene on human breast cancer cells.

Abstract Source:

Int J Clin Exp Pathol. 2014 ;7(7):3948-56. Epub 2014 Jun 15. PMID: 25120771

Abstract Author(s):

Chaying Guan, Weiguo Liu, Yongfang Yue, Hongchuan Jin, Xian Wang, Xiao-Jia Wang

Article Affiliation:

Chaying Guan

Abstract:

It has been approved for the clinical application ofβ-elemene to treat various cancers mainly brain tumors in China. In the present study, we found that β-elemene significantly inhibited the in vitro growth of human breast cancer cells by inducing apoptosis. In addition, β-elemene also induced the conversion of LC3-I into LC3-II as well as the formation of autolysosomes, indicating the activation of autophagy. Interestingly, inhibition of autophagy significantly potentiated the growth-inhibitory effect of β-elemene on breast cancer cells. In summary, β-elemene induced cytoprotective autophagy in human breast cancer cells in addition to apoptosis. Inhibition of autophagy significantly enhanced the cytotoxicity of β-elemene to human breast cancer cells. Therefore, combination of β-elemene with autophagy inhibitors could be a promising strategy for the treatment of breast cancer.

Study Type : In Vitro Study

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Sayer Ji
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