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Abstract Title:

Anti-tumor activity evaluation of novel chrysin-organotin compound in MCF-7 cells.

Abstract Source:

Bioorg Med Chem Lett. 2015 Nov 23. Epub 2015 Nov 23. PMID: 26670842

Abstract Author(s):

Hong-Zhuan Xuan, Jun-Hong Zhang, Yue-Hua Wang, Chong-Luo Fu, Wei Zhang

Article Affiliation:

Hong-Zhuan Xuan

Abstract:

Chrysin (5,7-dihydroxylflavone, Chry) is a natural flavonoid extracted from plants and propolis. In this work, a novel chrysin-organotin (Chry-Sn) compound with enhanced anticancer activities was synthesized by the reaction of chrysin and triphenyltin chloride, and its potential anticancer effects against cancer cells were measured using various methods. Sulforhodamine B (SRB) results showed that chrysin and Chry-Sn had significant inhibition effects on the proliferation of MCF-7, A549 and HeLa human cancer cell lines in a dose- and time- dependent manner. These results suggested that Chry-Sn possessed enhanced anticancer effects. Hoechst 33258 staining and acridine orange staining results showed apoptosis and nuclei fragments significantly increased after being treated with chrysin and Chry-Sn respectively. Moreover, chrysin and Chry-Sn significantly increased ROS levels in MCF-7 cells. Western blot results showed that chrysin and Chry-Sn activated caspase 3 and induced autophagy by increasing LC3-II level. All results showed collectively that Chry-Sn could be a more promising drug than chrysin in anticancer treatment.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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