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Abstract Title:

Chemical constituents from Taraxacum officinale and theirα-glucosidase inhibitory activities.

Abstract Source:

Bioorg Med Chem Lett. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29254644

Abstract Author(s):

Janggyoo Choi, Kee Dong Yoon, Jinwoong Kim

Article Affiliation:

Janggyoo Choi

Abstract:

Three novel butyrolactones (1-3) and butanoates (4-6), namely taraxiroside A-F, were isolated from Taraxacum officinale along with twenty-two known compounds (7-28). Their chemical structures were elucidated by interpretation of spectroscopic data and comparison with those of literatures. All isolates were evaluated for theirα-glucosidase inhibitory activities. Novel compounds 1-6 (IC50 145.3-181.3 μM) showed inhibitory activities similar to that of acarbose (IC50 179.9 μM). Compound 7 and 12 were the most potent inhibitor with IC50 values of 61.2 and 39.8 μM respectively. Compounds 2 and 12 showed as mixed-type inhibition, whereas compound 7 and acarbose showed competitive inhibition.

Study Type : In Vitro Study

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Sayer Ji
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