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Abstract Title:

Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.

Abstract Source:

J Nat Med. 2016 Apr ;70(2):234-40. Epub 2016 Jan 30. PMID: 26833191

Abstract Author(s):

Yan-Hong Shi, Shu Zhu, Takayuki Tamura, Makoto Kadowaki, Zhengtao Wang, Kayo Yoshimatsu, Katsuko Komatsu

Article Affiliation:

Yan-Hong Shi

Abstract:

The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker,β-hexosaminidase release with IC50 values of 40.34 and 25.05 μM, respectively. A primary structure-activity relationship of these components was discussed.

Study Type : In Vitro Study

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Sayer Ji
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