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Abstract Title:

Characteristics and immune-enhancing activity of pectic polysaccharides from sweet cherry (Prunus avium).

Abstract Source:

Food Chem. 2018 Jul 15 ;254:47-54. Epub 2018 Jan 31. PMID: 29548470

Abstract Author(s):

Jinping Cao, Dandan Tang, Yue Wang, Xian Li, Li Hong, Chongde Sun

Article Affiliation:

Jinping Cao

Abstract:

Two water soluble polysaccharides components PAPS-1 and PAPS-2 with homogeneously distributed molecular weight were obtained from Prunus avium. PAPS-1 and PAPS-2 contained GalA: Ara: Gal: Rha: GluA: Glu in 49.38: 32.39: 10.68: 4.66: 1.94: 0.48 and 77.18: 14.91: 3.39: 3.46: 0.93: 0.19 M ratios respectively, as well as trace amount of mannose and fucose. Infrared spectroscopy (IR), nuclear magnetic resonance (NMR) and methylation analysis indicated that both fractions were type I rhamnogalacturonan (RG-I) pectic polysaccharides with glycan side chains constituted mainly of arabinose with minor amount of galactose. Galacturonic acid methylation and sugar acetylation was found in both PAPS-1 and PAPS-2. Both PAPS-1 and PAPS-2 significantly induced the NO release from RAW264.7 cells and the expression of several immune-related molecular (TNFα, IL6, IL10, GCSF, iNOS, COX-2)was induced in RAW264.7 cells.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

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