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Article Publish Status: FREE
Abstract Title:

Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts.

Abstract Source:

Complement Med Res. 2019 Mar 20:1-4. Epub 2019 Mar 20. PMID: 30897582

Abstract Author(s):

Paul G Werthmann, Lothar Kindermann, Gunver S Kienle

Article Affiliation:

Paul G Werthmann

Abstract:

INTRODUCTION: Metastatic renal cell carcinoma has a poor prognosis. Treatment approaches with immunotherapy show promising results in subpopulations. Viscum album extracts - used as an adjunct to cancer treatment - have cytotoxic, apoptogenic, and immune-stimulating properties and show synergistic effects with chemotherapy agents.

CASE REPORT: A 51-year-old man was diagnosed with metastatic renal cell carcinoma of clear cell histology which was classified as pT3a, N1, M1, G3. Nephrectomy was performed, and the patient received chemoimmunotherapy (interferon-α2a, interleukin-2, fluorouracil, isotretinoin). Additionally, he received V. album extracts as intravenous infusions and subcutaneous injections. One year after surgery, the patient was in complete remission, which is ongoing 18 years after the initial diagnosis.

DISCUSSION: This case shows an extraordinarily long survival of a metastasized renal cell carcinoma patient under chemoimmunotherapy and fever-inducing V. album extracts. This combined treatment might have synergistically contributed to tumor remission and control. With regard to clinical relevance, further investigations are needed.

Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(397) : AC(152)

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Sayer Ji
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