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Abstract Title:

Carvacrol activity&morphological changes in Mycobacterium tuberculosis.

Abstract Source:

Future Microbiol. 2018 06 1 ;13:877-888. Epub 2018 Jun 7. PMID: 29877104

Abstract Author(s):

Sandra S Nakamura de Vasconcelos, Katiany R Caleffi-Ferracioli, Laíse A Hegeto, Vanessa P Baldin, Celso V Nakamura, Talitha F Stefanello, Gisele de Freitas Gauze, Diego As Yamazaki, Regiane Bl Scodro, Vera Ld Siqueira, Rosilene F Cardoso

Article Affiliation:

Sandra S Nakamura de Vasconcelos

Abstract:

AIM: Evaluating carvacrol, derivatives and carvacrol plus anti-TB (anti-tuberculous) drug combination activities in Mycobacterium tuberculosis as well as carvacrol cytotoxicity, efflux pump inhibitor activity and morphological changes in M. tuberculosis HRv.

METHODS: Carvacrol (CAR) and derivatives' activities were determined by resazurin microtiter assay and drug interaction by resazurin drug combination microtiter. Carvacrol cytotoxicity in VERO cells and efflux pumps inhibitor activity by ethidium bromide assay were determined and scanning electron microscopy performed.

RESULTS: Carvacrol MIC ranged from 19 to 156 μg/ml and carvacrol plus rifampicin combination showed synergistic effect in clinical isolates. No anti-M. tuberculosis activity improvement was observed with carvacrol derivatives. Carvacrol showed to be selective for M. tuberculosis, to have efflux pumps activity and to induce rough bacillary and agglomerates.

CONCLUSION: Carvacrol shows good anti-M. tuberculosis activity and synergism with rifampicin.

Study Type : In Vitro Study

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