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Abstract Title:

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3.

Abstract Source:

Arch Pharm Res. 2019 Mar ;42(3):274-283. Epub 2018 Nov 15. PMID: 30430364

Abstract Author(s):

In Jun Yeo, Ju Ho Park, Jun Sung Jang, Do Yeon Lee, Jung Eun Park, Ye Eun Choi, Jung Hun Joo, Joo Kyung Song, Hyung Ok Jeon, Jin Tae Hong

Article Affiliation:

In Jun Yeo

Abstract:

Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has been reported to inhibit inflammation. Carnosol, a major component of Rosemary, has prominent anti-inflammatory effects. However, its protective effect on UVB-induced inflammatory skin responses has not yet been reported. Here, we investigated the effectiveness of carnosol on UVB-induced inflammation. We examined the anti-inflammation effect of topical application of carnosol (0.05 µg/cm) on UVB (540 mJ/cm, for 3 successive days)-induced skin inflammation in HR1 mice. Topical application of carnosol inhibited UVB-induced erythema, epidermal thickness, inflammatory responses in HR1 mice. Carnosol reduced the level of Immunoglobulin-E and IL-1β in blood serum of UVB-induced mice. Carnosol also significantly inhibited the UVB-induced expression of inflammatory marker protein (iNOS and COX-2) in back skin of mice. In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes. Ourstudy suggested that carnosol has protective effects on skin inflammatory skin damages by UVB.

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Sayer Ji
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